B-Cell-Activating Factor and the B-Cell Compartment in HIV/SIV Infection
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چکیده
منابع مشابه
B-Cell-Activating Factor and the B-Cell Compartment in HIV/SIV Infection
With the goal to design effective HIV vaccines, intensive studies focused on broadly neutralizing antibodies, which arise in a fraction of HIV-infected people. Apart from identifying new vulnerability sites in the viral envelope proteins, these studies have shown that a fraction of these antibodies are produced by self/poly-reactive B-cells. These findings prompted us to revisit the B-cell diff...
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Introduction Increased B cell activating factor (BAFF) in the serum of juvenile-onset systemic lupus erythematosus (JSLE) patients is thought to be key to the survival of autoreactive B cells. BAFF signals through three receptors, BAFF-R, BCMA and TACI, activating the NFB pathway. Belimumab is a human monoclonal antibody against BAFF that has recently become the first drug licensed for the trea...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01338